Click the image to paper

NN_KIM 복사본  20170518_063654.png cover.tif_-1

40. Seong-Hwan Hwang, Yongsoo Ra, Somang Paeng, and Hyoung F. Kim
Paper about 3 salience components that guide your habitual eye movement.
Motivational salience component is always in the background to control your eye movements.
It’s beneficial in relearning of forgotten values.
Coming soon…

39. Hyoung F. Kim

Brain substrates for automatic retrieval of value memory in the primate basal ganglia

Molecular Brain volume 14, Article number: 168 (2021)



38. Joonyoung Kang, Hyeji Kim, Seong Hwan Hwang, Minjun Han, Sue-Hyun LeeHyoung F. Kim


“Our human and macaque monkey data propose a role of the VS as a “director” that guides habitual behavior with the script of value information written in the past.”     -in the paper-

The 1st research paper using human & non-human primate in Korea!


<NEWS link>


37. Kim HF*, Griggs W, Hikosaka O. (* corresponding author)

Long-term value memory in the primate posterior thalamus for fast automatic action

Current Biology 2020 June Online publication

What brain circuit generates our fast automatic action?

습관행동을 형성하는 뇌회로의 지름길이 있을까? 라는 질문에서 시작해서, 기존 시각회로를 우회하여 학습된 시각자극이 시상(thalamus)를 거쳐 직접 행동을 조절할 수 있는 지름길 뇌회로를 밝힘.

36. Amita H, Kim HF, Inoue KI, Takada M, Hikosaka O.

Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift.

Nat Commun. 2020 Apr 20;11(1):1876.

35. Amita H, Kim HF, Smith MK, Gopal A, Hikosaka O.

Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia.

Eur J Neurosci. 2019 Mar;49(5):712-725.

34. Hikosaka O, Kim HF, Amita H, Yasuda M, Isoda M, Tachibana Y, Yoshida A.

Direct and indirect pathways for choosing objects and actions.

Eur J Neurosci. 2019 Mar;49(5):637-645.

33. Jiang H and Kim HF

Anatomical Inputs From the Sensory and Value Structures to the Tail of the Rat Striatum.

Front. Neuroanat., 2018 May 3;12:30.

30. Whitney S. Griggs†, Hyoung F. Kim†, Ali Ghazizadeh, M. Gabriela Costello, Kathryn M. Wall and Okihide Hikosaka (†Equal contribution)

Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs

Front. Neuroanat., 24 November 2017 | 

29. Kim HF*, Amita H, Hikosaka O (* corresponding author)

Indirect pathway of caudal basal ganglia for rejection of valueless visual objects


Banner image created by Kim HF.

Neuron 2017, May 94(4): 920-930

28. Yu NK, Kim HF, Shim J, Kim S, Kim DW, Kwak C, Sim SE, Choi JH, Ahn S, Yoo J, Choi SL, Jang DJ, Lim CS, Lee YS, Kang C, Choi SY, Kaang BK.

A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.

Sci. Rep. 2016 Mar

27. Kim HF*, Ghazizadeh A, Hikosaka O (* corresponding author)

Dopamine neurons encoding long-term memory of object value for habitual behavior

Cell 2015, Nov 19(5): 1165-75

26. Kim HF* and Hikosaka O (* corresponding author)

Parallel basal ganglia circuits for voluntary and automatic behavior to reach reward

Brain 2015,

25. Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK.

Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis.

Exp. Neurobiol. 2015 Sep;24(3):246-51

24. Kim HF*, Ghazizadeh A, Hikosaka O (* corresponding author)

Separate groups of dopamine neurons innervate caudate head and tail encoding flexible and stable value memories.

Front. Neuroanat. 2014, 8:120. doi: 10.3389/fnana.2014.00120

23. Hikosaka O, Kim HF, Ysuda M, Yamamoto S

Basal ganglia circuits for reward value-guided behavior.

Annu Rev Neurosci. 2014 Aug;37:289–306.

22. Kim HF* and Hikosaka O (* corresponding author)

Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values.

Cover article in Sep. issueCover art by Kim HF

Neuron 2013 Sep 4;79(5): 1001-1010

21. Hikosaka O, Yamamoto S, Yasuda M, Kim HF

Why skill matters.

Cover article in Sep. issue.

Trends Cogn Sci. 2013 Sep;17(9):434-41

20. Yamamoto S, Kim HF, Hikosaka O.

Reward value-contingent changes of visual responses in the primate caudate tail associated with a visuomotor skill.

J Neurosci. 2013 Jul 3;33(27):11227-38.

19. Lee YS, Choi SL, Jun H, Yim SJ, Lee JA, Kim HF, Lee SH, Shim J, Lee K, Jang DJ, Kaang BK.

AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15520-5.

18. Lee SH, Kwak C, Shim J, Kim JE, Choi SL, Kim HF, Jang DJ, Lee JA, Lee K, Lee CH, Lee YD, Miniaci MC, Bailey CH, Kandel ER, Kaang BK.

A cellular model of memory reconsolidation involves reactivation-induced destabilization and restabilization at the sensorimotor synapse in Aplysia.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14200-5.

17. Jang DJ, Park SW, Lee JA, Lee C, Chae YS, Park H, Kim MJ, Choi SL, Lee N, Kim H, Kaang BK.

N-termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes.

Learn Mem. 2010 Sep 2;17(9):469-79.

16. Park SW, Ko HG, Lee N, Lee H, Rim Y, Kim H, Lee KM, Kaang BK.

Aged wild-type littermates and APPswe+PS1/ΔE9 mice present similar deficits in associative learning and spatial memory independent of amyloid load.

Genes & Genomics. 2010 Feb 32: 63-70

15. Lee YS, Choi SL, Lee SH, Kim H, Park H, Lee N, Lee SH, Chae YS, Jang DJ, Kandel ER, Kaang BK.

Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14634-9.

14. Kaang BK, Lee SH, Kim H

Synaptic Protein Degradation as a Mechanism in Memory Reorganization.

Neuroscientist. 2009 Oct;15(5):430-5

13. Lee JS, Jang DJ, Lee N, Ko HG, Kim H, Kim YS, Kim B, Son J, Kim SH, Chung H, Lee MY, Kim WR, Sun W, Zhuo M, Abel T, Kaang BK, Son H.

Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors.

J Neurosci. 2009 Jul 1;29(26):8493-505

12. Lee YS, Choi SL, Kim TH, Lee JA, Kim HK, Kim H, Jang DJ, Lee JJ, Lee S, Sin GS, Kim CB, Suzuki Y, Sugano S, Kubo T, Moroz LL, Kandel ER, Bhak J, Kaang BK.

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18602-7.

11. Lee SH, Choi JH, Lee N, Lee HR, Kim JI, Yu NK, Choi SL, Lee SH, Kim H, Kaang BK.

Synaptic protein degradation underlies destabilization of retrieved fear memory.

Science. 2008 Feb 29;319(5867):1253-6.

10. Lee SH, Lim CS, Park H, Lee JA, Han JH, Kim H, Cheang YH, Lee SH, Lee YS, Ko HG, Jang DH, Kim H, Miniaci MC, Bartsch D, Kim E, Bailey CH, Kandel ER, Kaang BK.

Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia.

Cell. 2007 May;18;129(4):801-12.

9. Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK.

PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation.

J Cell Biol. 2006 Sep 11;174(6):827-38.

8. Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK.

Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation.

J Neurochem. 2006 Jul;98(2):420-9.

7. Kim H, Lee SH, Han JH, Lee JA, Cheang YH, Chang DJ, Lee YS, Kaang BK.

A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in Aplysia neurons.

Neuron. 2006 Mar 2;49(5):707-18.

6. Jang DH, Han JH, Lee SH, Lee YS, Park H, Lee SH, Kim H, Kaang BK.

Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16072-7.

5. Park H, Lee JA, Lee C, Kim MJ, Chang DJ, Kim H, Lee SH, Lee YS, Kaang BK.

An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation.

J Neurosci. 2005 Sep 28;25(39):9037-45.

4. Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK.

Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system.

J Neurosci Res. 2003 Jul 15;73(2):255-9.

3. Kim H, Chang DJ, Lee JA, Lee YS, Kaang BK.

Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein.

Neurosci Lett. 2003 Jun 5;343(2):134-8.

2. Lee JA, Lim CS, Lee SH, Kim H, Nukina N, Kaang BK.

Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons.

J Neurochem. 2003 Apr;85(1):160-9.

1. Lee JA, Kim H, Lee YS, Kaang BK.

Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses.

Neurosci Lett. 2003 Jan 30;337(1):9-12.